There’s an exciting discovery from scientists at Western University that could change how we tackle some major health problems.
They’ve been studying something found in sweet oranges and tangerines, a molecule called nobiletin, and it turns out it might be a big help in fighting obesity, diabetes, and heart disease.
These researchers were curious about how this nobiletin works, so they did some experiments with mice. They fed one group of mice a diet that was high in fat and cholesterol – kind of like a lot of fast food.
But here’s the twist: some of these mice also got nobiletin. The results were pretty impressive. The mice that had nobiletin in their diet ended up much leaner than the ones who didn’t.
They also had lower levels of blood fats and were less resistant to insulin, which is a big deal when it comes to preventing diabetes.
The team also looked at mice who were already dealing with obesity and all the health issues that come with it. They found out that giving these mice nobiletin could actually turn things around for them.
It even started to reduce the buildup of plaque in their arteries. That’s the stuff that can lead to heart attacks and strokes, so it’s a major finding.
The scientists had a hunch that nobiletin was affecting a specific part of the body’s system that deals with fat. There’s this thing called AMP Kinase, which is like a control switch for burning fats and making energy.
It also stops the body from making too much fat. The researchers initially thought nobiletin was working on this AMP Kinase. But, surprise! It turns out nobiletin doesn’t mess with AMP Kinase at all. It’s doing its thing through a different route.
This detail is actually really important. Because nobiletin doesn’t work on the AMP Kinase, it means it shouldn’t cause problems with other medicines that do.
That’s good news for future treatments because it could potentially work alongside other drugs without causing unwanted reactions.
This research was published in the Journal of Lipid Research and and the team was led by Murray Huff.
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